Open-Label Trial of Recombinant Human Insulin-like Growth Factor 1/Recombinant Human Insulin-like Growth Factor Binding Protein 3 in Myotonic Dystrophy Type 1

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منابع مشابه

Open-label trial of recombinant human insulin-like growth factor 1/recombinant human insulin-like growth factor binding protein 3 in myotonic dystrophy type 1.

OBJECTIVE To evaluate the safety and tolerability of recombinant human insulin-like growth factor 1 (rhIGF-1) complexed with IGF binding protein 3 (rhIGF-1/rhIGFBP-3) in patients with myotonic dystrophy type 1 (DM1). DESIGN Open-label dose-escalation clinical trial. SETTING University medical center. PARTICIPANTS Fifteen moderately affected ambulatory participants with genetically proven ...

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Optimization and Construction of Human Insulin-like Growth Factor 1 Gene related to human health

Background and aims: Laron syndrome is a disease that treated by Insulin-like Growth Factor 1 (IGF-1). This protein is a single chain and has three disulfide bonds. People with Laron syndrome have low rates of cancer and diabetes, although they appear to be at increased risk of casual death due to their stature. IGF-1 is synthesized by many tissues and is secreted from liver as an endocrine hor...

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The role of insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in human esophageal cancer.

BACKGROUND Insulin-like growth factors (1GF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play important roles in cell growth and differentiation. The aim of this work was to investigate the roles of IGF-1 and IGFBP-3 in esophageal cancer. MATERIALS AND METHODS We examined the circulating IGF-1 and IGFBP-3 concentration in 18 healthy controls and 66 esophageal cancer patients ...

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Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.

BACKGROUND A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. OBJECTIVE We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in mid...

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Production and functional characterization of human insulin-like growth factor 1

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ژورنال

عنوان ژورنال: Archives of Neurology

سال: 2011

ISSN: 0003-9942

DOI: 10.1001/archneurol.2010.227